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Progress in the research of carbon nanotubes as drug carriers

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 10

DOI:: 10.3321/j.issn:0513-4870.2008.10.002

Key Word:: 碳纳米管;功能化修饰;药物载体;低毒性

Abstract：新型药物载体的开发对药物的研究具有举足轻重的作用.碳纳米管具有独特的中空结构和纳米管径,可用作药物载体.采用肽、蛋白、核酸及药物分子修饰的碳纳米管作为载体,可运载生物活性分子进入细胞且不产生毒性.本文综述了近年来修饰碳纳米管作为药物载体的研究进展,评述了碳纳米管的细胞穿透性能和细胞毒性,概述了碳纳米管功能化修饰的方法.随着碳纳米管在药物载体领域研究日趋深入,碳纳米管修饰方式与其细胞穿透性能的相互关系、尺寸效应将会深入研究.制备溶解性好、低毒性的修饰碳纳米管作为药物载体,将是今后研究的主要方向.

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