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Progress in the studies on small molecule IGF-1R inhibitors
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2008.10.001
- Key Word:
- 胰岛素样生长因子1受体;小分子激酶抑制剂;肿瘤;进展
Abstract： 胰岛索样生长因子1受体(IGF-1R)的信号转导途径与肿瘤的发生密切相关.抑制IGF-1R的活性,可以有效控制肿瘤细胞的生长和转移,并增强肿瘤对化疗、放疗的敏感性.以IGF-1R为靶标的治疗方法中,IGF-1R单克隆抗体和小分子激酶抑制剂已进入临床试验阶段.本文对近年来以IGF-1R为靶点的小分子激酶抑制剂的研究进展进行综述.
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