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Role of ventricular M3 receptor in arrhythmia resulted from cerebral-cardiac syndrome
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- No doi available
- Key Word:
- M3受体;脑心综合征;心律失常;钙
Abstract： 观察M3受体(M3R)在脑心综合征(CCS)模型大鼠心室肌中的作用及其表达,以探讨其与CCS心律失常的关系.线栓法建立CCS模型,监测心电图,激光共聚焦扫描显微镜记录激动M3R后心肌细胞内钙的变化,Western blotting检测心室肌中M3R表达水平的改变.同对照组相比,模犁组心电图QRS、QT间期显著延长(P＜0.01);Western blotting结果显示模型组心室肌中M 3R的表达水平较对照组显著降低(P＜0.05);胆碱激动M3R可以抑制KCl除极诱导的模型组心肌细胞内钙的升高幅度(P＜0.01),其特异阻断剂4-DAMP可以阻断这一作用.M3R表达降低可能是CCS心律失常的重要原因之一.激动M3R可以降低心肌细胞内钙,M3R可能是治疗CCS心律失常新的靶点.
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