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Action and resistance mechanisms of capreomycin: a functional genomic perspective
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- No doi available
- Key Word:
- 卷曲霉素;生物合成基因簇;结核病;耐药机制
Abstract： 随着一线抗结核药物的长期和广泛使用,结核病耐药性亦不断增加,其中耐多药结核分枝杆菌和持留菌感染已经成为结核病有效防治的关卡.寻找新型抗结核药物迫在眉睫.卷曲霉素被认为是较理想的二线结核病治疗药物,也是开发新的肽类结核病药物的模板.本文综述了从功能基因组学角度研究卷曲霉素的生物合成基因簇、转录组水平的作用机制和细菌耐药新机制,为合理使用卷曲霉素和开发新一代肽类抗生素提供借鉴.
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