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Advances in the study of berberine and its derivatives

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 8

DOI:: No doi available

Key Word:: 天然产物;小檗碱;衍牛物;构效关系;药物设计

Abstract：小檗碱是从中草药黄连等植物中提取分离得到的一类异喹啉类生物碱.近十年来,已经有2 000多篇国内外文献报道了小檗碱及其衍生物在治疗肿瘤、糖尿病、心血管疾病、高血脂、炎症、细菌和病毒感染、脑缺血性损伤、精神疾病、阿尔茨海默病(Alzheimer disease)、骨质疏松等多方面的临床应用、药效机制以及该类化合物的构效关系等研究结果.这些结果表明小檗碱生理功能广泛,潜在的结构改造和开发应用价值很大,但还未见系统的回顾和综述.本文对这些文献进行了系统地分析整理,主要从临床应用与药效机制、分子药理、体内吸收代谢、构效关系四个方面来介绍小檗碱及其衍生物的研究进展,旨在为进一步深入开展以药效机制为基础的小檗碱结构改造和创新药物研究提供比较系统的信息.

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