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Advances in the study of molecular mechanism of APOBEC3G anti-HIV-1

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 7

DOI:: 10.3321/j.issn:0513-4870.2008.07.002

Key Word:: APOBEC3G;人类免疫缺陷病毒1型;胞嘧啶脱氨;病毒感染因子;泛素化

Abstract：载脂蛋白B mRNA编辑酶催化多肽样蛋白3G(apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 protein G, APOBEC3G)属于固有免疫家族成员,具有胞嘧啶脱氨酶活性,在HIV-1复制过程中通过与HIV-1的Gag蛋白相互作用,选择性包装进入病毒毒粒.在HIV-1的逆转录过程中,APOBEC3G通过催化病毒负链cDNA中的dC脱氨为dU,在病毒基因组中引入广泛的超突变,从而发挥抗病毒作用.除了胞嘧啶脱氨机制外,APOBEC3G还能通过某些非脱氨机制抑制HIV-1的活性,但具体机制尚需深入研究.HIV-1编码的Vif蛋白可以通过泛素-蛋白酶体的降解途径来拮抗APOBEC3G的抗病毒活性.APOBEC3G具有广谱的抗病毒活性,可显著抑制多种逆转录病毒,逆转录转座子和乙型肝炎病毒(HBV)等的活性.上调APOBEC3G的表达水平或抑制Vif对APOBEC3G的拮抗可能成为治疗HIV-1感染的新的有效方法.

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