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Recent progress in the study on antitumor drugs targeting hypoxia-inducible factor-1

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 6

DOI:: 10.3321/j.issn:0513-4870.2008.06.003

Key Word:: 缺氧诱导因子-1;肿瘤;缺氧

Abstract：缺氧诱导因子-1(hypoxia inducible factor-1,HIF-1)是调控肿瘤内缺氧效应的一个重要因子,它能引起肿瘤细胞的无氧糖酵解、引发肿瘤的血管生成、促进肿瘤细胞的增殖、侵袭及迁移等行为,使这些肿瘤细胞在缺氧微环境下得以存活并使肿瘤的恶性程度进一步增强.它还能引发肿瘤对放/化疗的耐受,其表达程度与预后不良成正相关.它的发现为人们靶向肿瘤缺氧来开发新型抗肿瘤药物提供了一个潜在的分子靶点.本文综述了近年来靶向缺氧诱导因子HIF-1的抗肿瘤药物研究进展.

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