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Advances in the MDCK-MDR1 cell model and its applications to screen drug permeability

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 6

DOI:: 10.3321/j.issn:0513-4870.2008.06.002

Key Word:: MDCK-MDR1细胞;P-糖蛋白;药物转运;细胞模型

Abstract：本文介绍了MDCK-MDR1细胞系的特点、模型的建立,药物在其细胞模型上吸收转运的研究进展.概述了国内外关于利用MDCK-MDR1细胞系作为模型进行药物筛选、药物相互作用和研究药物吸收转运机制等方面的内容.MDCK-MDR1细胞系高表达P-糖蛋白(P-glycoprotein,P-gp),且P-gp呈极性分布,因而它可以作为药物转运模型快速筛选P-gp底物和抑制剂,以及肠道、血脑屏障、肾脏的体外模型.

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