Research progress on interactions between luteolin (glucosides) and drug-metabolizing enzyme

( views:, downloads: )
Author:
YING Jing-yan()
GU Shao-jun()
YAO Tong-wei()
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
Volume 43, Issue 04, 2008
DOI:
Key Word:

Abstract:

  • [1]Ko WG,Kang TH,Lee SJ,etal.Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid]eukaemia cells[J].Phytother Res,2002,16:295-298.
  • [2]Kimata M,Shichijo M,Miura T,et al.Effects of luteolin,quercetin and baicalein on immunoglobulin Emediated mediator release from human cultured mast cells[J].Clin Ex Allergy,2000,30:501-508.
  • [3]Nielsen SE,Breinhoh V,Justesen U,etal.In vitro biotransformation of flavonoids by rat liver microsomes[J].Xenobiotica,1998,28:389 -401.
  • [4]Xu YP,Yao TW.Study and Application of Chinese Herbal Medicine Fingerprints in Quality Control and in vitro Absorption and Metabolism (中药指纹图谱及其在中药质量控制和体外吸收代谢研究中的应用)[D].Hangzhou:Zhejiang University,2005.
  • [5]WiLliamson G,Day AJ,Plumb GW,et al.Human metabolic pathways of dietary flavonoids and cinnamates[J].Biochem Soc Trans,2000,28:16-22.
  • [6]Boersma MG,Woude H,Bogaards J,et al.Regioselectivity of phase Ⅱ metabolism of luteolin and quercetin by UDP-glucuronosyl transferases[J].Chem Res Toxicol,2002,15:662-670.
  • [7]Shimoi K,Nakayama T.Glucuronidase deconjugation in inflammation[J].Methods Enzymol,2005,400:263 -272.
  • [8]Ng SP,Wong KY,Zhang L,et al.Evaluation of the first-pass glucuronidation of selected flavones in gut by Caco-2 monolayer model[J].J Pharm Pharm Sci,2004,8:1 -9.
  • [9]Gradolatto A,Canivenc-Lavier MC,Basly JP,et al.Metabolism of apigenin by rat liver phase Ⅰ and phase Ⅱ enzymes and by isolated perfused rat liver[J].Drug Metab Dispos,2004,32:58-65.
  • [10]Spencer JP,Chowrimootoo G,Choudhury R,et al.The small intestine can both absorb and glueuronidate luminal flavonoids[J].FEBS Lett,1999,458:224-230.
  • [11]Oliverira EJ,Watson DG.In vitro glucuronidation of kaempferol and quercetin by human UGT-IA9 microsomes[J].FEBS Lett,2000,471:1-6.
  • [12]Li LP,Jiang HD.Determination and assay validation of luteolin and apigenin in human urine after oral administration of tablet of Chrysanthemum morifolium extract by HPLC[J].J Pharm Biomed Anal,2006,41:261-265.
  • [13]Zimmermann C,Gutmann H,Hruz P,et al.Mapping of multidrug resistance gene 1 and multidrug resistanceassociated protein isoform 1 to 5 mRNA expression along the human intestinal tract[J].Drug Metab Dispos,2005,33:219-224.
  • [14]Hu M,Chen J,Lin H.Metabolism of flavonoids via enteric recycling:mechanistic studies of disposition of apigenin in the Caco-2 cell culture model[J].J Pharmacol Exp Ther,2003,307:314-321.
  • [15]Ebert B,Seidel A,Lampen A.Identification of BCRP as transporter of benzo[a] pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists[J].Carcinogenesis,2005,26:1754-1763.
  • [16]Shimui K,Okada H,Furugori M.Intestinal absorption of luteolin and luteolin 7-O-beta-glueoside in rats and humans[J].FEBS Lett,1998,438:220-224.
  • [17]Walgren RA,Lin JT,Kinne RK,et al.Cellular uptake of dietary flavonoid quercetin 4'-beta-glucoside by sodium-dependent glucose transporter SGLT1[J].J Pharmacul Exp Ther,2000,294:837-843.
  • [18]Arts IC,Sesink AL,Hollman PC.Quercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestine[J].J Nutr,2002,132:630-632.
  • [19]Berrin JG,McLauchlan WR,Needs P,et al.Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris.Insights into its role in the metabolism of dietary glucosides[J].Eur J Biochem,2002,269:249-258.
  • [20]Day AJ,Ca(n)ada FJ,Diz JC,et al.Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase[J].FEBS Lett,2000,468:166-170.
  • [21]Neeth K,Plumb GW,Ben'in JG,et al.Deglycosylation by small intestinal epithelial cell beta-glueosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans[J].Eur J Nutr,2003,42:29-42.
  • [22]Li LP,Jiang HD.Metabolism of Chrysanthemum morifolium extract by intestinal tract flora[J].Chin Tradit Herb Drugs (中草药),2006,37:1001-1004.
  • [23]Chen T,Li LP,Lu XY.Absorption and excretion of luteolin and apigenin in rats after oral administration of Chrysanthemum morifolium extract[J].J Agric Food Chem,2007,55:273-277.
  • [24]Dimmock JR,Elias DW,Beazely MA,et al.Bioactivities of chalcones[J].Curr Med Chem,1999,6:1125-1149.
  • [25]Lin YT,Hsiu SL,Hou YC,et al.Degradation of flavonoid aglycones by rabbit,rat and human fecal flora[J].Biul Pharm Bull,2003,26:747 -751.
  • [26]Kim H J,Lee SB,Park SK,et al.Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP1A and CYP1B1 enzymes[J].Arch Pharm Res,2005,28:1114-1121.
  • [27]Foti RS,Wahlstrom JL,Wienkers LC.The in vitro drug interaction potential of dietary supplements containing multiple herbal components[J].Drug Metab Dispos,2007,35:185-188.
  • [28]Zhang S,Qin CH,Safe SH.Flavonoids as aryl hydrocarbon receptor agonists/antagonists:effects of structure and cell context[J].Environ Health Perspeet,2003,111:1877-1882
  • [29]Maliakal PP,Wanwimolruk S.Effect of herbal teas on hepatic drug metabolizing enzymes in rats[J].J Pharm Pharrnacol,2001,53:1323-1329.
  • [30]Walle UK,Walle T.Induction of human UDP-Glueuronosyhransferase UGT1A1 by flavonoids-structural requirements[J].Drug Metab Dispos,2002,30:564 -569.
  • [31]Morimitsu Y,Sugihara N,Furuno K.Inhibitory effect of flavonoids on sulfo-and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations[J].Biol Pharm Bull,2004,27:714 -717.
  • [32]Junko S,Kasumi Y,Eri T,et al.The induction of human UDP-glucuronosyhransferase 1A1 mediatedthrough a distal enhancer module by flavonoids and xenobiotics[J].Biochem Pharmacol,2004,67:989-1000.
  • [33]Molna J,Gyeant N,Mucsi I,et al.Modulation of multidrug resistance and apoptosis of cancer cells by selected earotenoids[J].In Vivo,2004,18:237-244.
  • [34]Ugocsai K,Varga A,Molnar P,et al.Effects of selected flavonoids and earotenoids on drug accumulation and apoptosis induction in muhidrug-resistant colon cancer cells expressing MDR1/LRP[J].In Vivo,2005,19:433-438.
  • [35]Zhang S,Yang X,Morris ME.Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport[J].Mol Pharmacol,2004,65:1208-1216.
  • [36]van Zanden JJ,Wortelboer HM,Bijlsma S,et al.Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2[J].Biochem Pharmacol,2005,69:699-708.
  • [37]Boumendjel A,Di Pietro A,Dumontet C,et al.Recent advances in the discovery of flavonoids and analogs with high-affinity binding to P-glycoprotein responsible for cancer cell multidrug resistance[J].Med Res Rev,2002,22:512-529.
  • [38]Di Pietro A,Conseil G,Perez-Victoria JM,et al.Modulation by flavonoids of cell multidrug resistance mediated by P-glyeoprotein and related ABC transporters[J].Cell Mol Life Sci,2002,59:307 -322.
  • [39]van Zanden JJ,Geraets L,Wortelboer HM,et al.Structural requirements for the flavonoid-mediated modulation of glutathione S-transferase P1-1 and GS-X pump activity in MCF7 breast cancer cells[J].Biochem Pharmacol,2004,67:1607-1617.
  • [40]Nissler L,Gebhardt R,Berger S.Flavonoid binding to a multi-drug-resistance transporter protein:an STD-NMR study[J].Anal Bioanal Chem,2004,379:1045-1049.
  • [41]Walle T.Absorption and metabolism of flavonoids[J].Free Radic Biol Med,2004,36:829-837.
  • [42]Spencer JP,Abd-el-Mohsen MM,Rice-Evans C,et al.Cellular uptake and metabolism of flavonoids and their metabolites:implications for their bioaetivity[J].Arch Biochem Biophys,2004,423:148-161.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn