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Research progress on interactions between luteolin (glucosides) and drug-metabolizing enzyme

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 4

DOI:: 10.3321/j.issn:0513-4870.2008.04.002

Key Word:: 木犀草素;药物代谢;细胞色素P450;Caco-2细胞

Abstract：综述木犀草素及其苷的各相代谢研究及其与药物代谢酶的相互作用.木犀草素的代谢主要受二相代谢酶介导,其苷首先在肠道被水解成苷元,再被吸收,代谢.木犀草素对一相代谢酶CYP3A有诱导作用,而对CYP1A,1B和2E有强抑制作用,此外木犀草素也是CYP286,CYP2C9和CYP2D6有效的抑制剂;木犀草素对二相代谢酶SULTs有强抑制作用;并对多种ABC转运蛋白有抑制作用.了解木犀草素及其苷与药物代谢酶的相互作用,对其临床安全合理用药具有重要指导意义.

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