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Heat shock proteins: new target in cytoprotective and tumor therapy

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 3

DOI:: 10.3321/j.issn:0513-4870.2008.03.002

Key Word:: 热休克蛋白;细胞凋亡;肿瘤免疫

Abstract：热休克蛋白(heat shock proteins,HSPs)作为分子伴侣帮助变性的蛋白质重新折叠成天然构象,清除严重损伤的蛋白质.内源性HSPs在细胞凋亡调控中发挥着重要的作用,使细胞适应环境的变化并且能在致死性刺激下生存,决定着细胞的命运.HSPs在肿瘤细胞中高表达,抑制HSP90对肿瘤治疗具有重要意义.HSPs可以从细胞释放到循环系统中,这些外源性的HSPs可以作为细胞因子在免疫调节中发挥重要作用.外源性HSP70在肿瘤治疗中具有广阔的前景,特殊的HSP复合体的发现和对其特性的了解为小分子抗肿瘤治疗提供了新策略.HSPs在细胞凋亡和肿瘤生物学领域中可以作为一种新型的分子药理学靶点.

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