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Effect of resveratrol on chronic obstructive pulmonary disease in rats and its mechanism
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2008.02.004
- Key Word:
- 白藜芦醇;慢性阻塞性肺疾病;支气管肺泡灌洗液;细胞间粘附分子-1
Abstract： 研究白藜芦醇对大鼠慢性阻塞性肺疾病的作用及可能的机制.单次气管注射博莱霉素(BLM)及连续27 d烟熏建立大鼠COPD模型,检测动脉血气参数变化、肺功能指标,测定支气管肺泡灌洗液(BALF)中细胞间粘附分子-1(ICAM-1)含量,检测肺湿/干重(W/D)比值,观察组织病理学变化.实验发现,白藜芦醇能抑制大鼠COPD的PaO2的下降,升高FEV0.3/FVC的比值,降低BALF中ICAM-1的含量,降低肺W/D比值,减轻肺组织病理学损伤.结果提示,白藜芦醇对大鼠COPD具有干预作用,其作用机制可能与抑制炎症因子的释放有关.
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