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Advances in the study of molecular mechanisms, applications and screening for altered peptide ligand
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2008.02.001
- Key Word:
- 修饰性肽配体;分子作用机制;噬菌体展示;肽库
Abstract： 修饰性肽配体是在抗原表位的基础上对表位进行氨基酸改造形成的具有免疫调节活性的短肽,已经在治疗自身免疫疾病、恶性肿瘤和病毒感染等疾病方面显示出良好的应用前景.一方面,修饰性肽配体可通过影响天然抗原表位、主要组织相容性复合体和T细胞受体形成的三分子结构发挥特异性免疫调节作用;另一方面,修饰性肽配体还可通过改变抗原呈递细胞内信号、旁路抑制和激发异源性免疫反应等机制发挥治疗作用.结合使用噬菌体展示技术对肽库进行筛选,可获得大量高特异性和高亲和力修饰性肽配体.修饰性肽配体作为潜在抗原特异性药物的重要来源正在受到广泛关注.
- [1]F R, Fischer,L, Santambrogio,Y, Luo,etc.Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression.[J].2000,110(1-2).
- [2]Uhlin M,Levitsky V,Masucci M.Is the activity of partially agonistic MHC:peptide ligands dependent on the quality of immunological help?[J].2006,64(6).
- [3]Singh RA,Zhang JZ.Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand.[J].2004,173(12).
- [4]Kuchroo VK,Nicholson L,Lowe LD,etc.IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis.[J].2000,164(7).
- [5]Moysey R,Boulter J,Dunn SM,etc.Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.[J].2006,15(4).
- [6]Badiga Venkata Aruna,Michael Sela,Edna Mozes.Suppression of myasthenogenic responses of a T cell line by a dual altered peptide ligand by induction of CD4~+CD25~+ regulatory cells[J].2005,102(29).
- [7]Sanna A,Hussien Y,Huang YM,etc.Glatiramer acetate and IFN-beta act on dendritic cells in multiple sclerosis.[J].2001,121(1).
- [8]Sato AK,De Souza M,Gorzelany J,etc.Phage display-derived peptides as therapeutic alternatives to antibodies.[J].2004,9(12).
- [9]Beddoe T,Miles JJ,Kjer Nielsen L,etc.Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection.[J].2005,174(9).
- [10]Zakhaleva V,Scheinberg DA,Korontsvit T,etc.Synthetic peptide analogs derived from bcr/abl fusion proteins and the induction of heteroclitic human T-cell responses.[J].2005,90(10).
- [11]Li R,Li X,Li Z.Altered collagen II peptides inhibited T-cell activation in rheumatoid arthritis.[J].2006,118(2).
- [12]Bielekova B,Martin R.Antigen-specific immunomodulation via altered peptide ligands.[J].2001,79(10).
- [13]Sela M,Mozes E,Aruna BV.Down-regulation of T cell responses to AChR and reversal of EAMG manifestations in mice by a dual altered peptide ligand via induction of CD4(+)CD25(+) regulatory cells.[J].2006,177(1).
- [14]Ben David H,Sela M,Mozes E,etc.A dual altered peptide ligand down-regulates myasthenogenic T cell responses and reverses experimental autoimmune myasthenia gravis via up-regulation of Fas-FasL-mediated apoptosis.[J].2006,118(3).
- [15]Kwok WW,Narvanen A,Saarelainen S,etc.Potential of an altered peptide ligand of lipocalin allergen Bos d 2 for peptide immunotherapy.[J].2007,119(4).
- [16]Alleva DG,Kipnes MS,Conlon PJ,etc.Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope.[J].2006,63(1).
- [17]Barba P,Del-Pozzo G,Mascolo D,etc.Phage display of a CTL epitope elicits a long-term in vivo cytotoxic response.[J].2007,50(1).
- [18]Li Z,Li X,Li R.Influenza virus haemagglutinin-derived peptides inhibit T-cell activation induced by HLA-DR4/1 specific peptides in rheumatoid arthritis.[J].2006,24(2).