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Recent advances in the study of Pin1 and its inhibitors

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
1
DOI:
10.3321/j.issn:0513-4870.2008.01.002
Key Word:
肽脯氨酰异构酶;Pin1抑制剂;肿瘤;综述

Abstract: Pin1是一个新的肽脯氨酰异构酶,特异性地催化蛋白质中磷酸化的Ser/Thr-Pro酰胺键的顺反异构,改变蛋白质的构象,调控蛋白质的功能.抑制Pin1的表达和活性,可抑制肿瘤细胞的生长.Pin1抑制剂有望发展成为新作用机制的抗癌药物.本文综述了近年来Pin1及其抑制剂研究的最新进展.

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