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Biology of thioredoxin and its association with Alzheimer's disease and Parkinson's disease

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 1

DOI:: 10.3321/j.issn:0513-4870.2008.01.001

Key Word:: 硫氧还蛋白;生物学;阿尔茨海默病;帕金森病

Abstract：硫氧还蛋白(thioredoxin,Trx)是一种具有氧化还原活性的小分子蛋白质,具有抗氧化、抗凋亡、调节转录因子活性等功能,在氧化还原调节和细胞信号转导中发挥重要作用.本文对哺乳动物的Trx及其与阿尔茨海默病(AD)和帕金森病(PD)的关系的研究进展进行综述.基于Trx的神经保护活性,增加Trx的表达可望成为AD和PD防治的新靶点.

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