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Advances in the study of expression and regulation of P-glycoprotein
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2007.09.001
- Key Word:
- P-糖蛋白;多药耐药;转录因子;基因
Abstract： 积极外排异物是细胞适应外界环境的主要机制,由此产生的多药耐药是肿瘤化疗失败的首要原因.由MDR1基因编码的P-糖蛋白的高表达导致药物外排增加是MDR发生的主要机制.最近研究发现,转录因子(transcription factor)、DNA甲基化、组蛋白乙酰化程度以及磷酸化、糖基化、泛素化和MDR1基因多态性在P-糖蛋白调控过程中起重要作用,有望成为提高肿瘤化疗效果的治疗新靶点,本文将近年来相关研究进展作一综述.
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