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Recent advances in the biosynthesis of taxol

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 4

DOI:: 10.3321/j.issn:0513-4870.2007.04.003

Key Word:: 紫杉醇;生物合成途径;组合表达

Abstract：紫杉醇是一种抗癌新药.紫杉醇及其衍生物还具有防治移植动脉硬化、抗瘢痕形成和抗血管生成等功能.目前,人们获得紫杉醇的方法主要有以下几种:直接从红豆杉中提取;化学全合成;化学半合成;细胞培养;内生真菌提取培养及代谢工程生产紫杉醇.已从红豆杉中克隆出了至少14个和紫杉醇生物合成相关的基因并进行了功能鉴定.紫杉醇生物合成途径的阐明带动了紫杉醇前体组合表达系统的研究.

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