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A novel class of anti-inflammatory and analgesic drugs——NO-donating NSAIDs

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
4
DOI:
10.3321/j.issn:0513-4870.2007.04.002
Key Word:
一氧化氮;一氧化氮供体;非甾体抗炎药;一氧化氮供体型非甾体抗炎药

Abstract: 传统的非甾体抗炎药(NSAIDs)和环氧化酶-2(COX-2)选择性抑制剂临床应用极为广泛,但严重的胃肠道和新近发现的心血管不良反应限制了它们进一步的应用.一氧化氮(NO)供体型NSAIDs (NO-NSAIDs)的研发是近年来减少NSAIDs和COX-2选择性抑制剂不良反应的重要策略,此类药物既具有NSAIDs的抗炎、镇痛作用,又具有NO介导的胃肠道和心血管保护作用.本文简要介绍NO-NSAIDs的化学,重点综述NO-NSAIDs的药理特点、作用机制以及一些潜在的治疗应用.

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