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Preparation of magnetic solid liposome nanoparticles of paclitaxel
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2006.10.005
- Key Word:
- 紫杉醇;磁性;靶向;脂质体;肿瘤
Abstract： 目的 研究一种制备高载药量的紫杉醇磁性脂质体纳米粒的最佳条件,并对其质量进行检测.方法 通过共沉淀法制备Fe3O4纳米粒,同时施加超声处理减少粒子的软团聚合,增加粒子的分散度,对粒子表面进行改性,增加与脂质的结合,最后通过微乳液-低温固化法合成紫杉醇磁性脂质体纳米粒,并通过反相高压液相色谱法检测药物的载药量和包封率.结果 紫杉醇磁性脂质体纳米粒为球形或近似球形,其悬浮液样品和冻干样品的粒径约在150～170 nm,药物包封率为98.29%.结论 本法制备的粒子具有高质量磁化率、良好磁响应性,符合作为纳米磁靶向给药系统的条件.
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