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Hypertrophy of the heart:calcineurin-NFAT pathway may be a new therapeutic target

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 10

DOI:: 10.3321/j.issn:0513-4870.2006.10.001

Key Word:: calcineurin-NFAT通路;心肌肥厚;病理性心肌重构

Abstract： @@ 通常所说的心肌肥厚指病理性心肌重构(remodeling),从不同角度的分类包括结构性重构、功能性重构、生化重构及电生理重构等.一般认为,心肌肥厚是心肌对压力负荷、体积负荷、肌小节蛋白变异或心梗后心肌收缩力下降等的代偿性反应,目的是使左心室室壁压力正常化,维持正常的心脏泵血功能,阻止心脏衰竭的发生和发展.随着研究的深入进行,一项多中心回顾性流行病学调查发现[1-3],与原来的实验预期相反,心肌肥厚与心脏病的高死亡率密切相关,是心衰和恶性心律失常发生的主要因素.

Reference

[1]张英俊,梅和珊,王川,等.转录因子NFATc在钙神经素介导的脑缺血再灌注损伤中的作用[J].2005,(4).
[2]Jeffery D Molkentin,Jian-Rong Lu,Christopher L Antos,etc.A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy[J].1998,93(2).
[3]Huang B,Qin D,El-Sherif N.Early down-regulation of K+ channel genes and currents in the postinfarction heart.[J].2000,11(11).
[4]J, Yang,B, Rothermel,R B, Vega,etc.Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles.[J].2000,87(12).
[5]Weiss RM,Bassel Duby R,Demetroulis E,etc.Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function.[J].2002,277(12).
[6]D, Levy,R J, Garrison,D D, Savage,etc.Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study.[J].1990,322.
[7]G R, Crabtree.Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT.[J].1999,96(5).
[8]Naga-Prasad SathyamanglaV,Esposito Giovanni,Rapacciuolo Antonio,etc.Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress.[J].2002,105(1).
[9]Olson EN,Frey N,Cobb M,etc.Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy.[J].2001,20(11).
[10]Eva, van Rooij,Pieter A, Doevendans,Harry J G M, Crijns,etc.MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction.[J].2004,94(3).
[11]Booz GW.Putting the brakes on cardiac hypertrophy: exploiting the NO-cGMP counter-regulatory system.[J].2005,45(3).
[12]Gwathmey J,Force T,del-Monte F,etc.Differential activation of signal transduction pathways in human hearts with hypertrophy versus advanced heart failure.[J].2001,103(5).
[13]Bueno, Orlando F.,Wilkins, Banjamin J.,Tymitz, Kevin M.,etc.Impaired cardiac hypertrophic response in Calcineurin Aβ-deficient mice.[J].2002,99(7).
[14]Leslie A. Leinwand.Calcineurin inhibition and cardiac hypertrophy: A matter of balance[J].2001,98(6).
[15]Lim HW,Molkentin JD.Calcineurin and human heart failure (letter) (see comments)[J].1999,5(3).
[16]Papst PJ,Vega RB,Roberts CR,etc.Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5[J].2004,24(19).
[17]S A, Akhter,L M, Luttrell,H A, Rockman,etc.Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy.[J].1998,280.
[18]I A, Graef,P G, Mermelstein,K, Stankunas,etc.L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons.[J].1999,401(6754).
[19]Norian LA.,Latinis KM.,Koretzky GA.,etc.Two Nfat Transcription Factor Binding Sites Participate in the Regulation of Cd95 (Fas) Ligand Expression in Activated Human T Cells[J].1997,272(50).
[20]N, Frey,E N, Olson.Cardiac hypertrophy: the good, the bad, and the ugly.[J].2003,65.
[21]Rick B. Vega,Timothy A. McKinsey,Beverly A. Rothermel.Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo[J].2001,98(6).
[22]Zou Y,Hiroi Y,Uozumi H,etc.Calcineurin plays a critical role in the development of pressure overload-induced cardiac hypertrophy.[J].2001,104(1).
[23]De Windt-LJ,Lim HW,Molkentin JD,etc.Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy.[J].2000,97(3).
[24]Molkentin JD,Wilkins BJ.Calcineurin and cardiac hypertrophy: where have we been? Where are we going?[J].2002,541(Pt.1).
[25]Leon J. De Windt,Orlando F. Bueno,Hae W. Lim.Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo[J].2001,98(6).
[26]Vega RB,Rothermel BA,Weinheimer CJ,etc.Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy.[J].2003,100(2).