You Position: Home > Paper
Effect of preparation technique on in vitro release mechanism of huperzine A microspheres
( views:134, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.2006.07.003
- Key Word:
- 石杉碱甲;乳酸-羟基乙酸共聚物微球;O/O型乳化溶剂挥发法;体外释放度;药物分布
Abstract： 目的考察制备工艺对石杉碱甲(Hup)乳酸-羟基乙酸共聚物(PLGA)微球体外释药机制的影响.方法采用两种O/O型乳化溶剂挥发法工艺(A法和B法)制备Hup微球.考察微球的体外释药曲线,结合微球在释放介质中的降解速度和溶胀速度曲线以及微球的形态和微球中药物的分布情况阐述微球的释药机制.结果采用A法制备的微球包封率为47.60%,体外无明显突释现象,可缓释35 d,符合零级动力学方程,通过扩散和降解两种机制释药.采用B法制备的微球包封率为83.50%,体外可缓释21 d,整体释药曲线符合Higuchi方程,主要以扩散机制释药.结论采用A法制备的微球具有更理想的缓释效果.
- [1]Akihiro Matsumoto,Yasuhisa Matsukawa,Takehiko Suzuki,etc.The polymer-alloys method as a new preparation method of biodegradable microspheres: principle and application to cisplatin-loaded microspheres[J].1997,48(1).
- [2]P Sansdrap,A.J Moës.In vitro evaluation of the hydrolytic degradation of dispersed and aggregated poly(dl-lactide-co-glycolide) microspheres[J].1997,43(1).
- [3]Iwata, M.,Nakamura, Y.,Mcginity, J. W..In vitro and in vivo release properties of brilliant blue and tumour necrosis factor-alpha (TNF-alpha) from poly(D,L-lacticco-glycolic acid) multiphase microspheres.[J].1999,16(6).
- [4]M. Kyo,S.-H. Hyon,Y. Ikada.Effects of preparation conditions of cisplatin-loaded microspheres on the in vitro release[J].1995,35(1).
- [5]P. Le Corre,J. H. Rytting,V. Gajan,etc.In vitro controlled release kinetics of local anaesthetics from poly(D, L-lactide) and poly(lactide-co-glycolide) microspheres[J].1997,14(2).
- [6]Q.PING,X.FU,Y.GAO.Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres[J].2005,22(1).
- [7]Yang YY,Chung TS,Ng NP.Morphology, drug distribution, and in vitro release profiles of biodegradable polymeric microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method.[J].2001,22(3).
- [8]Flanagan DR.,Al-Maaieh A..Salt and cosolvent effects on ionic drug loading into microspheres using an O/W method[J].2001,70(1).
- [9]Schafer UF,Lamprecht A,Lehr C.Characterization of microcapsules by confocal laser scanning microscopy: structure, capsule wall composition and encapsulation rate.[J].2000,49(1).
- [10]S. Izumikawa,S. Yoshioka,Y. Aso,etc.Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate[J].1991,15(2).