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Inhibitory effect of iguratimod on TNFα production and NF-κB activity in LPS-stimulated rat alveolar macrophage cell line

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
5
DOI:
10.3321/j.issn:0513-4870.2006.05.004
Key Word:
艾拉莫德;大鼠肺泡巨噬细胞系NR8383;肿瘤坏死因子α;核因子κB

Abstract: 目的研究非甾体抗炎药艾拉莫德(T-614)对脂多糖(LPS)刺激的大鼠肺泡巨噬细胞系(NR8383)前炎症反应因子TNFα基因表达、蛋白合成的影响及其对核因子κB(NF-κB)的作用.方法体外培养NR8383经T-614(13.4,26.7及53.4μmol·L-1)处理,LPS刺激后应用酶联免疫吸附法(ELISA)检测细胞上清液中TNFα的水平,半定量逆转录聚合酶链式反应(RT-PCR)检测TNFαmRNA水平,ELISA法检测NF-κB的活性.结果T-614对LPS诱导的NR8383细胞TNFα mRNA水平和蛋白水平的上调有显著抑制作用,对NF-κB的转录活性也有抑制作用.结论T-614可能通过抑制LPS诱导的NR8383的NF-κB活性而降低TNFα的产生.

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