You Position: Home > Paper
Advances in the study of glucokinase and small molecule glucokinase activators
( views:158, downloads:21 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.2006.05.002
- Key Word:
- 葡萄糖激酶;活化剂;2型糖尿病;进展
Abstract： @@ 近年来,全球糖尿病发病率增长迅速,糖尿病已经成为继肿瘤、心血管病之后第三大严重威胁人类健康的慢性疾病.据世界卫生组织预计,到2025年,全球成人糖尿病患者人数将增至3亿,而中国糖尿病患者人数将达到4 000万,未来50年内糖尿病仍将是中国一个严重的公共卫生问题.在糖尿病患者中90%以上为2型糖尿病,其特征为胰岛素分泌不足或不敏感引起高血糖症.
- [1]P, Zimmet,K G, Alberti,J, Shaw.Global and societal implications of the diabetes epidemic.[J].2001,414(6865).
- [2]Eiki JI,Mitsuya M,Nishimura T,etc.Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase[J].2004,12(3).
- [3]Yasuda K,Fyfe MC,Rasamison CM,etc.Glucokinase-activating ureas.[J].2005,15(5).
- [4]Cherrington AD,Mann SL,Davis SN,etc.Acute fructose administration improves oral glucose tolerance in adults with type 2 diabetes.[J].2001,24(11).
- [5]Johnstone C,Lackie S,Davies CD,etc.Discovery, synthesis and biological evaluation of novel glucokinase activators.[J].2005,15(8).
- [6]Kaleko M,Boettcher BR,Fanelli B,etc.Treatment of type 2 diabetes by adenoviral-mediated overexpression of the glucokinase regulatory protein.[J].2001,50(8).
- [7]Aiston S,Leighton B,Vertigan HL,etc.Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators.[J].2004,53(3).
- [8]Postic C,Fujimoto Y,Jetton TL,etc.Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.[J].2001,50(3).