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Transactivation of HIV-1 transcription and inhibitors

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 4

DOI:: 10.3321/j.issn:0513-4870.2006.04.001

Key Word:: HIV-1;转录;反式激活;抑制剂

Abstract： @@ 人免疫缺陷病毒1型(human immunodeficiencyvirus type 1,HIV-1)是一种RNA病毒,侵入细胞后,在HIV-1逆转录酶的作用下合成双链DNA.病毒双链DNA在整合酶的作用下嵌入宿主细胞的DNA.在没有反式激活因子(trans-activator of transcription,Tat)的情况下,整合的病毒DNA转录不完全,只有短的转录体生成.胞液中的Tat转导进入细胞核,与病毒新生RNA的反式激活应答区(trans-activator response region,TAR)相互作用,反式激活病毒RNA的转录,使得转录得以持续进行,生成完整的RNA.在HIV的复制周期中,转录的反式激活起着十分重要的调节作用[1],是艾滋病药物研究的理想靶点之一.

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