You Position: Home > Paper
Structural modification of cyclovirobuxine D and their inhibition activity on lipid peroxidation
( views:159, downloads:0 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 2
- DOI:
- 10.3321/j.issn:0513-4870.2006.02.005
- Key Word:
- 环维黄杨星D;结构改造;抗脂质氧化
Abstract： 目的以20或21-氨基甾体化合物为先导化合物,对植物活性单体--环维黄杨星D进行结构改造,以寻求抗脂质氧化活性更强的心脑血管药物.方法根据合理药物设计原理,设计合成目标化合物,并研究其抗脂质氧化活性.结果获得4个环维黄杨星D新衍生物,并经光谱证明了结构.结论采用硫代巴比妥酸(TBA)法测定脂质过氧化物(MDA),结果表明,部分化合物药理效果优于环维黄杨星D.
- [1]V. Mezesova,P. Racay,J. Lehotsky,etc.Membrane ion transport systems during oxidative stress in rodent brain: protective effect of stobadine and other antioxidants[J].1999,65(18).
- [2]X J, Liu,M H, Yao,T H, Fang,etc.[Some cardiovascular effects of cyclovirobuxine-D (author's transl)].[J].1982,3.
- [3]方泰惠,许惠琴,徐立,等.黄杨宁对急性实验性脑缺血的保护作用[J].1997,(7).