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Preparation of ondansetron hydrochloride osmotic pump tablets and their in vitro drug release
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 12
- DOI:
- 10.3321/j.issn:0513-4870.2005.12.005
- Key Word:
- 渗透泵片;盐酸昂丹司琼;控制释放;释放机制
Abstract： 目的制备盐酸昂丹司琼渗透泵型控释片剂(OND-OPT)并考察体外释药特性.方法以锅包衣法制备OND-OPT.通过释放度试验筛选处方并考察OND-OPT的释放特性;通过均匀设计试验建立持续释药时间与衣膜厚度、衣膜中PEG含量和释药孔孔径的关系;考察OND-OPT的释药机制.结果释药孔朝向对不含HPMC的制剂释药有明显影响,而对含HPMC的制剂释药无影响.持续释药时间与衣膜厚度和衣膜中PEG含量有关,与释药孔孔径无显著关系.OND-OPT主要以渗透泵机制释放药物.结论通过调节衣膜厚度和衣膜中PEG含量,OND-OPT可以实现理想的药物控制释放.
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