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Recent advances in the study of artemisinin-related 1,2,4-trioxanes and ozonides (1,2,4-trioxolanes) as antimalarials

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 12

DOI:: 10.3321/j.issn:0513-4870.2005.12.001

Key Word:: 青蒿素;抗疟药物;1,2,4-三恶烷;臭氧化物;构效关系;作用机制

Abstract： @@ 疟疾(malaria)是一种在热带、亚热带地区广泛传播的寄生虫病,世界的大半人口生活在这些疟疾流行的地区[1].据世界卫生组织(WHO)报告,疟疾每年会导致上亿人生病、200多万人死亡,其中大多数为非洲儿童.20世纪60年代,疟原虫对传统的抗疟药物如奎宁、氯喹等开始产生抗药性,使形势进一步恶化.

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