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Preparation and evaluation of self-microemulsifying drug delivery systems containing atorvastatin
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 11
- DOI:
- 10.3321/j.issn:0513-4870.2005.11.005
- Key Word:
- 微乳;自微乳释药系统;阿托伐他汀;伪三元相图;乳化剂;生物利用度
Abstract： 目的制备阿托伐他汀自微乳,为自微乳释药系统的处方设计和体内外评价提供参考.方法采用伪三元相图法研究不同乳化剂、助乳化剂和油相形成微乳的能力和区域,绘制不同处方组成的相图,在此基础上制备阿托伐他汀自微乳,比较温度、介质、稀释等因素对自微乳效率的影响,进行自微乳时间、所成微乳的形态、粒径分布、[英文作者]eta电位、含量和稳定性等体外评价Beagle犬体内药代动力学研究.结果理想的处方经分散后可得到平均粒径在
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