You Position: Home > Paper
The erosion behaviour of matrix tablets using polyethylene oxide matrices as hydrophilic polymer
( views:194, downloads:9 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2005.10.004
- Key Word:
- 聚氧乙烯;亲水凝胶骨架片;溶蚀速率
Abstract： 目的研究聚氧乙烯(PEO)亲水凝胶骨架片的溶蚀行为.方法直接压片法制备PEO高分子素片,并测定单一和混合PEO骨架片在水中的溶蚀速率,通过实验和建立数学模型的方法探讨PEO相对分子质量与溶蚀速率的关系.结果实验结果表明PEO骨架片的溶蚀速率与重均分子量遵循经验方程:k∝(M-w)-1.1304,该式中的指数(-1.130 4)与理论推导值(-1.241)有较好的吻合,该方程可以有效预测重均分子量范围在97.98×104～553.36×104的单一和混合PEO骨架片的溶蚀速率.结论PEO是一种优良的亲水骨架材料,本实验获得的溶蚀规律对于PEO亲水凝胶骨架片的设计将具有积极的指导意义.
- [1]聂淑芳,吴学明,刘宏飞,等.海藻酸钠骨架材料中药物释放的影响因素[J].2004,(7).
- [2]丁雪鹰,高申,张仰眉.聚氧乙烯在口服控释制剂中的应用[J].2004,(12).
- [3]Robert T. C. Ju,Phillip R. Nixon,Mahesh V. Patel.Drug release from hydrophilic matrices. 1. New scaling laws for predicting polymer and drug release based on the polymer disentanglement concentration and the diffusion layer[J].1995,84(12).
- [4]Yuasa H,Ozeki T,Kanaya Y.Control of medicine release from solid dispersion composed of the poly(ethylene oxide)-carboxyvinylpolymer interpolymer complex by varying molecular weight of poly(ethylene oxide).[J].1999,58(1).
- [5]P. BOTTENBERG,R. CLEYMAET,C. DE MUYNCK,etc.Development and Testing of Bioadhesive, Fluoride-containing Slow-release Tablets for Oral Use[J].1991,43(7).
- [6]D R, Swanson,B L, Barclay,P S, Wong,etc.Nifedipine gastrointestinal therapeutic system.[J].1987,83(6B).
- [7]Johnson B,Yang L,Fassihi R.Determination of continuous changes in the gel layer thickness of poly(ethylene oxide) and HPMC tablets undergoing hydration: a texture analysis study.[J].1998,15(12).
- [8]Robert T. C. Ju,Phillip R. Nixon,Mahesh V. Patel.Diffusion coefficients of polymer chains in the diffusion layer adjacent to a swollen hydrophilic matrix[J].1997,86(11).
- [9]C J, Kim.Drug release from compressed hydrophilic POLYOX-WSR tablets.[J].1995,84(3).