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Protective effects of ligustrazine against photoreceptor cell injury induced by N-methyl-N-nitrosourea and its mechanism
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- 10.3321/j.issn:0513-4870.2005.08.004
- Key Word:
- 川芎嗪;N-甲基-N-亚硝基脲;光感受器细胞;细胞凋亡
Abstract： 目的探讨川芎嗪对N-甲基-N-亚硝基脲(N-methyl-N-nitrosourea,MNU)致大鼠视网膜损伤的作用.方法大鼠生后47 d,腹腔注射不同剂量的川芎嗪注射液;50 d注射MNU 60 mg·kg-1.测量视网膜总厚度;TUNEL和RT-PCR法分别检测细胞凋亡、c-jun和c-fos的表达.结果川芎嗪注射液可剂量依赖性地增加周边视网膜总厚度和降低凋亡指数,并抑制MNU诱导的即早基因表达.结论川芎嗪通过下调基因c-jun和c-fos的表达,抑制光感受器细胞凋亡,从而部分保护MNU引起的视网膜损伤.
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