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A new target of cancer therapy: advances in the study of histone deacetylase

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Author:: No author available

Journal Title:: ACTA PHARMACEUTICA SINICA

Issue:: 7

DOI:: 10.3321/j.issn:0513-4870.2005.07.002

Key Word:: 组蛋白去乙酰酶;组蛋白乙酰酶;核小体;活性通道;活性部位

Abstract： @@ 随着生命科学的深入开展,有关肿瘤致病机制和发病机制的分子生物学研究为开发作用于特异性靶点的高效低毒的抗肿瘤药物奠定了基础.与肿瘤的发生和转移相关的蛋白种类繁多,而对肿瘤细胞生长调控有普遍生物学意义的蛋白才最有可能成为广谱低毒抗肿瘤药物的作用靶点.

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