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Anticonvulsant effect of phencynonate hydrochloride on maximal electroshock seizure and the metrazol seizure threshold test in mice

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
6
DOI:
10.3321/j.issn:0513-4870.2005.06.005
Key Word:
盐酸苯环壬酯;癫痫;N-甲基-D-天冬氨酸

Abstract: 目的评价盐酸苯环壬酯抗癫痫疗效,探讨其抗癫痫作用机制.方法建立不同癫痫发作模型,评价盐酸苯环壬酯等药物抗癫痫疗效;观察盐酸苯环壬酯等药物对致死剂量NMDA中毒小鼠、NMDA诱导的原代培养大鼠海马神经细胞损伤及NMDA诱发电流的影响.结果盐酸苯环壬酯在不同癫痫发作模型上均具明显抗惊作用;并可显著对抗致死剂量NMDA中毒,浓度依赖性抑制NMDA诱导原代培养大鼠海马神经细胞损伤及NMDA诱发电流.结论盐酸苯环壬酯在经典癫痫模型上均具显著抗惊作用,其作用机制可能与其对NMDA受体的拮抗作用有关.

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