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Modulation effect of bis (α-furancarboxylato)oxovanadium (IV) on blood glucose in diabetic rats
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0513-4870.2005.06.004
- Key Word:
- 双(α-呋喃甲酸)氧钒;糖尿病大鼠;血糖;胰岛素
Abstract： 目的研究双(α-呋喃甲酸)氧钒(VO-FA)对正常大鼠及链脲佐霉素(STZ)性糖尿病大鼠的降糖作用.方法以STZ诱导大鼠糖尿病模型.观察VO-FA灌胃给药后,对血糖、糖化血红蛋白、糖原和血清胰岛素等的影响.结果 VO-FA ig两周后,剂量依赖性地降低STZ性糖尿病动物的血糖水平,但对正常动物的血糖无影响.VO-FA 56.8 mg·kg -1可降低正常动物血清胰岛素水平,加倍剂量尚能降低STZ性糖尿病大鼠的血清胰岛素水平.此外,VO-FA 能降低糖尿病大鼠的糖化血红蛋白,明显改善糖耐量,增加肌糖原和肝糖原的含量,并呈现出量效关系,但对正常动物则没有影响.结论 VO-FA可以改善糖尿病动物的糖代谢,而不影响正常动物的血糖水平.
- [1]G W, Gould,G I, Bell.Facilitative glucose transporters: an expanding family.[J].1990,15(1).
- [2]S, Hauguel-de Mouzon,P, Peraldi,F, Alengrin,etc.Alteration of phosphotyrosine phosphatase activity in tissues from diabetic and pregnant rats.[J].1993,132(1).
- [3]Bénédicte A Reul,Sean S Amin,Jean-Pierre Buchet,etc.Effects of vanadium complexes with organic ligands on glucose metabolism: a comparison study in diabetic rats[J].1999,126(2).
- [4]Goldwaser I.,Gershonov E.,Fridkin M.,etc.Insulin-like effects of vanadium: basic and clinical implications[J].2000,80(1/2).
- [5]金文胜.钒酸盐对糖尿病大鼠糖原的影响与cAMP的关系[J].1998,(2).
- [6]Toshikazu Takino,Hiromu Sakurai,Rokuji Matsushita,etc.A new halogenated antidiabetic vanadyl complex, bis(5-iodopicolinato)oxovanadium(IV): in vitro and in vivo insulinomimetic evaluations and metallokinetic analysis[J].2001,6(2).
- [7]S M, Brichard,J C, Henquin.The role of vanadium in the management of diabetes.[J].1995,16(8).
- [8]Kobayashi M,Namba T,Takata Y,etc.Bellidifolin Stimulates Glucose Uptake in Rat 1 Fibroblasts and Ameliorates Hyperglycemia in Streptozotocin (Stz)-Induced Diabetic Rats[J].1995,61(5).
- [9]I A, Setyawati,K H, Thompson,V G, Yuen,etc.Kinetic analysis and comparison of uptake, distribution, and excretion of 48V-labeled compounds in rats.[J].1998,84(2).
- [10]Crans DC..Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds[J].2000,80(1).
- [11]Thompson Katherine,McNeill John H..Vanadium Compounds as lnsulin Mimics[J].1999,99(9).
- [12]Cam MC,Brownsey RW,McNeill JH.Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?[J].2000,78(10).
- [13]Maria Rangel,Hiromu Sakurai,Chihiro Fukushima,etc.In vitro study of the insulin-like action of vanadyl-pyrone and -pyridinone complexes with a VO(O_4) coordination mode[J].2001,6(2).