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High-throughput crystallization in pharmaceutical research and development
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 6
- DOI:
- 10.3321/j.issn:0513-4870.2005.06.001
- Key Word:
- 固体形态;高通量结晶技术;多晶现象;共晶
Abstract： @@ 1 前言药物固体剂型(片剂、颗粒剂,胶囊等)使用方便,贮存稳定,是市场上主要剂型.一种活性药物组分(active pharmaceutical ingredients, APIs)可能存在多种固体形式,包括多晶型、溶剂化物、水合物、共晶、无定形固体和盐(可能形成水合物、溶剂化物、多晶型、共晶和无定形固体),每种形式都呈现独特的物理化学性质,显著影响其溶解度、溶出速率、生物利用度、稳定性、可纯化性和加工性等药物的性能.所以,APIs固体形态的研究是药物开发过程的一个重要方面.一种药物的多种固体形态的发现不仅能为确定最佳药物固体形式提供更大的选择空间,而且还能获得知识产权保护.
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