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Effect of proanthocyanidins on COX-2 enzyme activity and COX-2 mRNA/protein expression in LPS-induced RAW264.7 cells

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
5
DOI:
10.3321/j.issn:0513-4870.2005.05.005
Key Word:
原花青素;环氧合酶-2;脂多糖;抗炎作用

Abstract: 目的探讨原花青素对脂多糖(LPS)诱导小鼠巨噬细胞株RAW264.7细胞COX-2酶活性及蛋白表达的影响.方法放射免疫法检测COX-2酶活性,RT-PCR检测COX-2 mRNA表达,Westem blotting检测COX-2蛋白表达.结果原花青素(0.8,4和20 mg·L-2)不影响LPS诱导RAW264.7细胞COX-2酶活性,可下调LPS诱导RAW264.7细胞COX-2mRNA表达;原花青素(4和20 mg·L-1)下调LPS诱导RAW264.7细胞COX-2蛋白表达.结论原花青素不影响LPS诱导RAW264.7细胞COX-2酶活性,但对LPS诱导RAW264.7细胞COX-2 mRNA及蛋白表达抑制作用明显.

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