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Vasodilation effect of atropine on rat mesenteric artery
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 5
- DOI:
- 10.3321/j.issn:0513-4870.2005.05.004
- Key Word:
- 阿托品;血管扩张作用;内皮细胞;血管平滑肌细胞;钙通道
Abstract： 目的研究阿托品的扩血管作用及机制.方法以大鼠肠系膜动脉为标本,考察阿托品对去甲肾上腺素(NE)预收缩血管的舒张作用以及血管内皮细胞、血管平滑肌在该效应中的作用.结果阿托品能显著舒张NE预收缩的完整内皮血管,去内皮后该作用明显降低.L-Nω-硝基精氨酸甲酯、吲哚美辛、普萘洛尔及格列本脲对阿托品的舒张作用无明显影响.阿托品对KCl的量效曲线及咖啡因缩血管作用均无明显影响,但能浓度依赖性地抑制NE诱导的内钙释放以及经受体操纵性钙通道的外钙内流.结论阿托品有明显的扩血管作用,其通过抑制受体介导的外钙内流和内钙释放而舒张血管.
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