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Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.2005.04.005
- Key Word:
- 银杏内酯B;血管生成;白介素-1β;肿瘤坏死因子
Abstract： 目的研究银杏内酯B对慢性炎症血管生成的作用及部分作用机制.方法比色法测定小鼠慢性肉芽肿气囊模型血管生成指数,组织形态学方法检测气囊病理变化;放射免疫方法测定白介素-1β(IL-1β)含量;L929生物测定法测定肿瘤坏死因子(TNF-α)含量;RT-PCR法检测IL-1β和TNF-αmRNA的表达.结果银杏内酯B可显著抑制模型小鼠的血管指数,与病理观察结果相符;银杏内酯B可显著抑制模型小鼠血清中IL-1和TNF-α的分泌;能显著抑制PMA诱导的U937细胞IL-1β和TNF-α的分泌及其mRNA的表达.结论银杏内酯B能抑制小鼠慢性炎症性血管生成模型的血管生成,能抑制促血管生成细胞因子IL-1β和TNF-α的转录及表达,这可能是其抑制慢性炎症血管生成的机制之一.
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