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Effects of enalapril on plasma Ang Ⅱ level and the expression of AT1 in blood vessel and kidney of type 2 diabetic rats
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0513-4870.2005.03.004
- Key Word:
- 依那普利;2型糖尿病大鼠;血管紧张素Ⅱ;血管紧张素Ⅱ1受体
Abstract： 目的研究依那普利对2型糖尿病大鼠血浆Ang Ⅱ和AT1受体表达的影响.方法用放射免疫法测定血浆Ang Ⅱ水平,免疫组化法观察血管和肾脏AT1受体表达.结果糖尿病大鼠血浆Ang Ⅱ明显高于对照组,应用依那普利后大鼠血浆Ang Ⅱ明显降低.免疫组化染色发现糖尿病大鼠血管内皮细胞、平滑肌细胞和肾脏AT1受体表达明显增加,依那普利治疗组大鼠血管内皮细胞、平滑肌细胞和肾脏AT1受体表达与正常组接近.结论糖尿病大鼠血浆Ang Ⅱ升高,血管和肾脏AT1受体表达增加,依那普利可降低糖尿病大鼠血浆Ang Ⅱ水平,下调血管和肾脏AT1受体表达.
- [1]杨俭,徐珊,李庆平,等.依那普利对2型糖尿病大鼠肠系膜血管内皮细胞的保护作用[J].2003,(6).
- [2]郭啸华,刘志红,李恒,等.实验性2型糖尿病大鼠模型的建立[J].2000,(4).
- [3]Huang XR,Chen WY,Truong LD,etc.Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease.[J].2003,14(7).
- [4]Harrison-Bernard, Lisa M.,Imig, John D.,Carmines, Pamela K..Renal AT 1 Receptor Protein Expression During the Early Stage of Diabetes Mellitus.[J].2002,3(2).
- [5]Jack A,Keegan A,Cotter M,etc.Effects of diabetes and evening primrose oil treatment on responses of aorta, corpus cavernosum and mesenteric vasculature in rats.[J].2002,71(16).
- [6]Osicka TM,Carey RM,Cao Z,etc.Renal expression of angiotensin receptors in long-term diabetes and the effects of angiotensin type 1 receptor blockade.[J].2002,20(8).