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Apoptosis of human carcinoma of mouth floor KB cells and multidrug resistant KBv200 cells induced by azide methyl anthraquinone derivative

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
1
DOI:
10.3321/j.issn:0513-4870.2005.01.005
Key Word:
叠氮甲基蒽醌衍生物;活性氧;线粒体跨膜电位;细胞凋亡

Abstract: 目的研究大黄素的蒽醌衍生物6-叠氮甲基-1-羟基-3,8-二甲氧基-9,10-蒽醌(AMAD-10)抑制KB细胞及其耐药株KBv200的生长和诱导细胞凋亡的作用.方法细胞毒用MTT法测定;细胞内活性氧(ROS)和线粒体跨膜电位(△ψm)分别用DCFH-DA和DiOC6荧光探针标记,流式细胞仪检测;Annexin V染色和DNA琼脂糖凝胶电泳检测AMAD诱导凋亡作用.结果AMAD浓度依赖性抑制KB和KBv200细胞的生长和引起活性氧明显增加,并能引起两种细胞△ψm时间依赖性的降低,AMAD可浓度依赖性地诱导两种细胞凋亡.结论AMAD体外显著抑制KB及其耐药株KBv200的生长,这可能与其引起细胞内ROS增加、使△ψm降低,从而诱导细胞凋亡有关.

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