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Effects of intragastric administration of thenorphine on morphine-induced behavioral sensitization in mice
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 12
- DOI:
- 10.3321/j.issn:0513-4870.2004.12.001
- Key Word:
- 噻诺啡;吗啡;行为敏化;自主活动
Abstract： 目的研究ig噻诺啡对小鼠吗啡行为敏化的影响.方法测定小鼠的自主活动,观察ig噻诺啡对小鼠自主活动及急性给予吗啡所诱导小鼠活动增强效应的影响;建立小鼠吗啡行为敏化模型,观察ig噻诺啡对行为敏化形成、转化及表达的影响.结果单次ig噻诺啡(1.25-5.0 mg·kg-1)可剂量依赖性地降低小鼠的自主活动(P＜0.01),但多次给药可产生耐受.噻诺啡可有效地抑制急性给予吗啡所诱导的小鼠高活动性(P＜0.05)及小鼠吗啡行为敏化的形成、转化和表达(P＜0.05或P＜0.01).结论噻诺啡可抑制小鼠中枢神经系统,对阿片类药物的滥用和成瘾可能具有干预作用.
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