Influence of N,N'-diacetyl-L-cystine on D-galactosamine/lipopolysaccharide induced immunological liver failure in mice
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 10
- DOI:
- 10.3321/j.issn:0513-4870.2004.10.004
- Key Word:
- N,N′-二乙酰-L-胱氨酸;暴发性肝衰竭;半乳糖胺;脂多糖;免疫调节剂;T细胞亚群;N,N'-diacetyl-L-cystine;fulminant heptic failure;galactosamine;lipopolysaccharide;immunomodulatory agent;T cell subsets
Abstract： Aim To study the therapeutic effects of N, N'-diacetyl-L-cystine (DiNAC) on immunological liver failure. Methods Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial period were analyzed by an automatic serum analyzer and a flow cytometer, respectively. The sectioned liver specimens were examined under a light microscope. And 24 h after the injection of Gal/LPS, the survival rate of rats was calculated. Results DiNAC (50, 200, 800 and differentiation of T cell subsets ( CD4 + , CD8 + and Th1, Th2), and improved all the histopathological features. In mice of fulminant hepatic failure (FHF), the survival time significantly prolonged and the survival rate increased 24 h after ip DiNAC. These effects were obviously dose-dependent. Conclusion DiNAC on mice with FHF has an inhibitory action which is related to immune mechanism.
- [1]H Louis,O Le Moine,MO Peny,etc.Hepatoprotective role of interleukin 10 in galactosamine/lipopolysaccharide mouse liver injury[J].1997,112(3).
- [2]Stina Boräng,Tove Andersson,Anders Thelin,etc.Monitoring of the subtraction process in solid-phase representational difference analysis: characterization of a candidate drug[J].2001,271(2).
- [3]Ann-Margret Ostlund-Lindqvist,Bengt Sarnstrand,Christer Westerlund,etc.N,N'-Diacetyl-L-cystine (DiNAC), the Disulphide Dimer of N-Acetylcysteine, Inhibits Atherosclerosis in WHHL Rabbits: Evidence for Immunomodulatory Agents as a New Approach to Prevent Atherosclerosis[J].2001,299(1).
- [4]Sarnstrand B,Matuseviciene G,Bergstrand H,etc.N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents.[J].1999,288(3).
- [5]杨天健,魏怀玲,刘耕陶.16种药物对卡介苗加脂多糖引起小鼠免疫性肝损伤的作用[J].1997,(2).