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Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2004.09.005
- Key Word:
- 苦参碱;胺碘酮;小檗胺;RP58866;钾通道
Abstract： 目的阐明苦参碱和小檗胺抗心律失常作用弱于胺碘酮和RP58866的分子机制.方法采用冠脉结扎、电刺激和乌头碱诱导的心律失常模型观察药物的抗心律失常作用,采用全细胞膜片钳技术测定单个心室肌细胞的IKl,IKr,IKs和Ito.结果苦参碱和小檗胺对冠脉结扎、乌头碱诱发的大鼠心律失常有明显对抗作用,对家兔电刺激致颤阈(VFT)有明显提高作用,但与胺碘酮和RP58866相比,抗心律失常作用明显低于前者.电生理结果显示:苦参碱和小檗胺对家兔IKl,IKr,IKs和犬Ito有抑制作用,但较胺碘酮和RP58866作用弱.结论苦参碱和小檗胺的抗心律失常作用及对IKl,IKr,IKs和Ito的抑制作用弱于胺碘酮和RP58866.
- [1]杨宝峰,单宏丽,周宇宏,等.一种筛选抗心律失常药物新模型的建立[J].2003,(2).
- [2]乔国芬,李柏岩.小檗胺对高钾，去甲肾上腺素及咖啡因引起大鼠心肌细胞内钙动拮?…[J].1999,020 (4).
- [3]艾静,高焕焕,何树庄,等.苦参碱、青蒿素和粉防己碱对豚鼠心室肌细胞胞浆钙的影响[J].2001,(6).
- [4]B Y, Li,G F, Qiao,Y L, Zhao,etc.Effects of berbamine on ATP-induced [Ca2+]i mobilization in cultured vascular smooth muscle cells and cardiomyocytes.[J].1999,20(8).
- [5]杨宝峰,李贵荣,徐长庆.RP58866对哺乳动物心室肌细胞跨膜钾电流的作用.[J].1999,(11).
- [6]Wang H,Yang B,Zhang L,etc.Direct block of inward rectifier potassium channels by nicotine.[J].2000,164(1).
- [7]G R, Li,B, Yang,H, Sun,etc.Existence of a transient outward K(+) current in guinea pig cardiac myocytes.[J].2000,279(1).
- [8]杨宝峰,李玉荣,徐长庆,等.Mechanisms of Artemisinin Antiarrhythmic Action[J].1999,(3).
- [9]Jutta Friese,Johannes Gleitz,Ulrike T Gutser,etc.Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties[J].1997,337(2-3).
- [10]S A, Rees,M J, Curtis.Specific IK1 blockade: a new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate.[J].1993,87(6).