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Optimization of microemulsion containing vinpocetine and its physicochemical properties
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2004.09.003
- Key Word:
- 长春西汀;微乳;经皮给药;单纯形网格法;Hacat细胞
Abstract： 目的选择适宜比例的油相、表面活性剂、助表面活性剂和水相制备长春西汀微乳制剂以增加药物的溶解度和经皮渗透量,优化处方,并对其理化性质和刺激性进行研究.方法绘制伪三元相图,确定各相的比例,以经皮稳态渗透流量为指标,利用单纯形网格法优化处方,并考察优化微乳的pH、粘度、电导率、折光率、粒径分布等理化性质.采用MTT法考察微乳制剂对人体皮肤细胞系模型Hacat细胞的毒性.结果O/W微乳在相图中的区域随着表面活性剂和助表面活性剂比例的增加而增加;单纯形网格优化法预测的指标值与实测值相近,所得的优化微乳性质稳定,对Hacat细胞无刺激性,与阴性组无显著性差异.结论长春西汀微乳制剂中药物的溶解度极大提高,经皮稳态渗透流量显著增大,安全稳定,可作为经皮给药的新型载体.
- [1]Daisuke KOBAYASHI,Takayasu MATSUZAWA,Kenji SUGIBAYASHI,etc.Feasibility of Use of Several Cardiovascular Agents in Transdermal Therapeutic Systems with l-Menthol-Ethanol System on Hairless Rat and Human Skin[J].1993,16(3).
- [2]H, Tohgi,K, Sasaki,K, Chiba,etc.Effect of vinpocetine on oxygen release of hemoglobin and erythrocyte organic polyphosphate concentrations in patients with vascular dementia of the Binswanger type.[J].1990,40(6).
- [3]Varshney M,Changez M.Aerosol-OT microemulsions as transdermal carriers of tetracaine hydrochloride.[J].2000,26(5).
- [4]Hsiu-O Ho,Chih-Chuan Hsiao,Ming-Thau Sheu.Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs[J].1996,85(2).
- [5]Zhong-Gao Gao,Han-Gon Choi,Hee-Jong Shin,etc.Physicochemical characterization and evaluation of a microemulsion system for oral delivery of cyclosporin A[J].1998,161(1).
- [6]Fentem JH,Botham PA.ECVAM's activities in validating alternative tests for skin corrosion and irritation.[J].2002,30(Suppl.2).
- [7]C, Faller,M, Bracher,N, Dami,etc.Predictive ability of reconstructed human epidermis equivalents for the assessment of skin irritation of cosmetics.[J].2002,16(5).
- [8]Niopas I,Ktistis G.A study on the in-vitro percutaneous absorption of propranolol from disperse systems.[J].1998,50(4).
- [9]Heylings JR,Diot S,Esdaile DJ,etc.A prevalidation study on the in vitro skin irritation function test (SIFT) for prediction of acute skin irritation in vivo: results and evaluation of ECVAM Phase III.[J].2003,17(2).
- [10]Peira E,Scolari P,Gasco MR.Transdermal permeation of apomorphine through hairless mouse skin from microemulsions.[J].2001,226(1).
- [11]Manuela T. Maya,João P. Pais,Henrique M. Araújo,etc.Determination of apovincaminic acid in human plasma by high-performance liquid chromatography[J].1996,14(5).