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Characterization of Me.PEG-PLA copolymer nanoparticles prepared by modified spontaneous emulsion-solvent evaporation
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2004.09.002
- Key Word:
- 聚乳酸;聚乙二醇;纳米粒;自乳化-溶剂挥发法
Abstract： 目的表征甲氧基封端的聚乙二醇/聚乳酸共聚物(Me.PEG-PLA)纳米粒.方法采用本体聚合合成了亲水改性的Me.PEG-PLA,用改进的自乳化-溶剂挥发法制备了该共聚物纳米粒.结果与结论1HNMR和FT-IR表征了共聚物结构为嵌段共聚物.原子力显微镜(AFM)对纳米粒的形态研究表明,未经PEG改性的PLA纳米粒呈规整的球形,而PEG改性的PLA纳米粒为核/壳结构,外壳为亲水性的PEG链段,内核为疏水的PLA.激光粒度仪测定共聚物纳米粒的zeta电势为零,进一步证明其核/壳结构.共聚物纳米粒的粒径在70～160 nm,并呈正态分布.
- [1]T Riley,T Govender,S Stolnik,etc.Colloidal stability and drug incorporation aspects of micellar-like PLA-PEG nanoparticles[J].1999,16(1-4).
- [2]Ha JC.,Lee YM.,Kim SY..Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres - II. Thermo-responsive drug release behaviors[J].2000,65(3).
- [3]Gref R.,Zambaux MF.,Alonso MJ. Labrude P.,etc.Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method[J].1998,50(1).
- [4]Yoo HS.,Park TG..Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer[J].2001,70(1).
- [5]Govender T,Davis SS,Ehtezazi T,etc.Defining the drug incorporation properties of PLA-PEG nanoparticles.[J].2000,199(1).
- [6]Gref R,Gorner T,Dellacherie E,etc.Lidocaine-loaded biodegradable nanospheres. I. Optimization Of the drug incorporation into the polymer matrix.[J].1999,57(3).
- [7]Jeon, H. J.,Jeong, Y. I.,Jang, M. K.,etc.Effect of solvent on the preparation of surfactant-free poly(dl-lactide-co-glycolide) nanoparticles and norfloxacin release characteristics[J].2000,207(1).