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Mechanisms of sodium ferulate inhibition of collagen synthesis in hepatic stellate cells
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 8
- DOI:
- 10.3321/j.issn:0513-4870.2004.08.001
- Key Word:
- 阿魏酸钠;肝星状细胞;胶原;转化生长因子β1
Abstract： 目的对阿魏酸钠抑制肝星状细胞合成胶原的机制进行探讨.方法3H-脯氨酸参入法检测胶原合成,ELISA方法检测阿魏酸钠对转化生长因子β1(TGFβ1)分泌的影响,Mv1Lu细胞增殖抑制实验考察阿魏酸钠对TGFβ1活性的影响.结果阿魏酸钠对TGFβ1处理条件下HSC-T6细胞中胶原的合成有抑制作用;能够降低HSC-T6细胞在氧化应激状态下TGFβ1的表达水平;对TGFβ1的活性有影响.结论阿魏酸钠抑制肝星状细胞合成胶原与其干预TGFβ1活性,减少氧化应激状态下HSC-T6细胞分泌TGFβ1的作用有关.
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