You Position: Home > Paper
Saivianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs
( views:156, downloads:19 )
- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.2004.07.004
- Key Word:
- 丹酚酸A;核苷转运抑制剂;抗肿瘤药物;肿瘤联合化疗
Abstract： 目的观察丹酚酸A(SAA)的抑制核苷转运活性及其抗肿瘤作用.方法用3H-TdR和3H-UR转运测定法,克隆生成测定法以及小鼠移植性肉瘤180模型.结果SAA抑制艾氏腹水癌细胞的胸苷和尿苷的转运,其IC50分别为18.1和17.1 μmol·L-1.SAA能明显增强5-FU、丝裂霉素c、MTX对KB细胞、肝癌BEL-7402细胞的细胞毒性.体内试验,SAA 200 mg·kg-1和5-FU 10 mg·kg-1单独使用的抑瘤率分别为41%和27%;SAA和5-FU联合使用的抑瘤率为63%(CDI=0.86).结论SAA有抑制肿瘤细胞核苷转运的活性,可增强5-氟尿嘧啶等药物的抗肿瘤作用,有可能用于肿瘤联合化疗.
- [1]黄云虹,甄永苏.大黄酸诱导肿瘤细胞凋亡及与丝裂霉素的协同作用[J].2001,(5).
- [2]刘颖琳,刘耕陶.丹酚酸-A体外对人血清低密度脂蛋白氧化修饰的抑制作用[J].2002,(2).
- [3]Y, Zhen,S, Cao,Y, Xue,etc.Green tea extract inhibits nucleoside transport and potentiates the antitumor effect of antimetabolites.[J].1991,6(1).
- [4]Tong-Jun Lin,Geng-Tao Liu,Yang Liu,etc.Protection by salvianolic acid A against adriamycin toxicity on rat heart mitochondria[J].1992,12(5).
- [5]Y S, Zhen,M S, Lui,G, Weber.Effects of acivicin and dipyridamole on hepatoma 3924A cells.[J].1983,43(4).
- [6]Smith PG,Curtin NJ,Marshman E,etc.Dipyridamole potentiates the in vitro activity of MTA (LY231514) by inhibition of thymidine transport.[J].2000,82(4).
- [7].Effects of Salvianolic Acid-a on Nih/3t3 Fibroblast Proliferation, Collagen Synthesis and Gene Expression[J].2000,(3).
- [8]S S, Cao,Y S, Zhen.Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B.[J].1989,24(3).
- [9]J, Su,Y S, Zhen,C Q, Qi,etc.[A fungus-derived novel nucleoside transport inhibitor potentiates the activity of antitumor drugs].[J].1994,29.
- [10]Jian Su,Yong-su Zhen,Chang-qing QiJi-lan Hu.Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs[J].1995,36(2).
- [11]杜冠华,裘月,张均田.丹酚酸A对大鼠心肌缺血再灌注性损伤的保护作用[J].1995,(10).
- [12]Lian-niang Li,Rui Tan,Wei-ming Chen.Salvianolic Acid A, a New Depside from Roots of Salvia miltiorrhiza[J].1984.
- [13]Y S, Zhen,J, Su,Y C, Xue,etc.Novel nucleoside transport inhibitors of natural origin.[J].1994,370.
- [14]N. L. LehmanP. V. Danenberg.Modulation of RTX cytotoxicity by thymidine and dipyridamole in vitro: implications for chemotherapy[J].2000,45(2).