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Effect of inhaled cyclosporin A on antigen-induced airway inflammation in asthmatic rats
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 7
- DOI:
- 10.3321/j.issn:0513-4870.2004.07.002
- Key Word:
- 环孢素A;气雾吸入;气道炎症;嗜酸性粒细胞
Abstract： 目的研究环孢素A(CsA)气雾吸入对抗原诱导的大鼠过敏性气道炎症的作用.方法用卵白蛋白(OA)致敏大鼠,2周后气雾吸入CsA(5,10,20g·L-1),每天1次,连续7 d.大鼠致敏后d20和d 21用OA(10g·L-1,每天1次)攻击,观察第2次OA攻击24h后支气管肺泡灌洗液及外周血中嗜酸性粒细胞的数量和支气管肺组织病理学改变情况,测定支气管肺泡灌洗液中TNF-α含量.结果CsA气雾吸入能明显降低支气管肺泡灌洗液及外周血中嗜酸性粒细胞的数量,减轻肺组织中炎症细胞特别是嗜酸性粒细胞的浸润,减轻组织水肿及上皮损伤等气道炎症状况,降低支气管肺泡灌洗液中TNF-α含量.结论CsA气雾吸入对大鼠过敏性气道炎症具有抑制作用,其作用机制与细胞因子TNF-α释放减少有关.
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