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Effects of hydrocortisone sodium succinate on sodium current in human and guinea pig cardiac myocytes
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 4
- DOI:
- 10.3321/j.issn:0513-4870.2004.04.003
- Key Word:
- 氢化可的松琥珀酸钠;人心房肌细胞;豚鼠心室肌细胞;钠电流
Abstract： 目的研究氢化可的松琥珀酸钠对人心房肌细胞和豚鼠心室肌细胞钠电流的影响.方法应用酶解法分离单个心肌细胞,应用全细胞膜片钳技术记录氢化可的松琥珀酸钠对钠电流的作用.结果氢化可的松琥珀酸钠(1,3,10 μmol·L-1)浓度依赖性地抑制人心房肌细胞和豚鼠心室肌细胞钠电流,IC50分别为6.97和8.74 μmol·L-1.氢化可的松琥珀酸钠不改变INa的最大激活电压.氢化可的松琥珀酸钠对钠电流的抑制作用起效快,见于用药后1～3 min.结论氢化可的松琥珀酸钠浓度依赖性地抑制钠电流,此作用出现快,提示可能与非基因组效应有关.
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