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Molecular mechanisms of antioxidant effects of propylene glycol mannate sulfate
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0513-4870.2004.01.004
- Key Word:
- 甘糖酯;丙二醛;超氧化物歧化酶;谷胱甘肽过氧化物酶;过氧化氢酶;二乙基二硫代氨基甲酸盐
Abstract： 目的探讨甘糖酯(PGMS)清除自由基抗氧化作用的分子机制.方法给大鼠ig高脂乳剂建立高脂血症模型,分成对照组、甘糖酯治疗组、甘糖酯+DDC组,治疗3周.检测血清、肝脏、脾脏和主动脉中丙二醛(MDA)的含量,超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT)的活性,以及Cu,Zn-SOD mRNA的表达水平.结果甘糖酯治疗组大鼠,丙二醛(MDA)含量降低,SOD,GSH-Px和CAT的活性显著升高,Cu,Zn-SOD mRNA的表达水平增加;而甘糖酯和DDC联合用药治疗组,DDC抑制了甘糖酯诱导的Cu,Zn-SOD mRNA表达水平和SOD活性的升高,造成MDA含量的相应升高.结论甘糖酯通过诱导抗氧化酶SOD,GSH-Px和CAT的活性,增加Cu,Zn-SOD mRNA的表达水平,清除体内过多的氧自由基,达到抗氧化的目的.
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