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Effect of indomethacin on expression of interleukin-6 caused by lipopolysaccharide in rheumatoid arthritic patients' synoviocyte

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Author:
No author available
Journal Title:
ACTA PHARMACEUTICA SINICA
Issue:
11
DOI:
10.3321/j.issn:0513-4870.2003.11.003
Key Word:
吲哚美辛;成纤维状滑膜细胞;白介素-6;脂多糖;U937细胞

Abstract: 目的研究吲哚美辛对脂多糖引起的人类风湿性关节炎(RA)成纤维状滑膜细胞(FLS)中白介素-6(IL-6)表达的影响.方法用放免分析法检测IL-6蛋白的表达水平; RT-PCR方法测定IL-6 mRNA的表达水平.结果LPS处理对FLS中IL-6表达无显著影响; LPS刺激的U937细胞培养液上清液可明显增强FLS 中IL-6蛋白分泌及mRNA表达; 吲哚美辛可显著抑制上述变化,且其抑制作用随浓度的增加而增强.结论吲哚美辛可抑制LPS刺激的U937细胞培养上清液引起的FLS中IL-6的表达.

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