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Antithrombotic effects of morpholine and piperazine ring derivatives and their molecular mechanism
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- Author:
- No author available
- Journal Title:
- ACTA PHARMACEUTICA SINICA
- Issue:
- 9
- DOI:
- 10.3321/j.issn:0513-4870.2003.09.001
- Key Word:
- 血管内皮细胞;乙酰胆碱;血栓;角叉菜胶
Abstract： 目的研究吗啉环和哌嗪环类衍生物对血栓形成的影响及分子机制.方法利用小鼠尾动脉血栓模型,观察新化合物对血栓形成的影响.结果化合物MOPMC,2FBMPC,MPTMBC,DMHPPP和PPVP在1.0 mg*kg-1可显著降低成栓率;而结构类似的化合物MAPC,4C3FBMOC,mTBMPC,MONVP和MPNVP对血栓形成均无明显影响;化合物DMHPPP对凝血系统和血小板聚集功能无显著影响,但可升高血浆中t-PA和PGI2含量,降低PAI-1的活性和TXA2的含量.结论吗啉环和哌嗪环类化合物可激活血管内皮细胞乙酰胆碱作用靶标而对抗血栓形成.
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